Cloned (Comment) | Organism |
---|---|
gene TPH2, cloning of four haplotypes of TPH2 into pcDNA3.1 and stable transfected into rat PC-12 cells, transient expressionin HEK-293 cells, quantitative real-time PCR expression analysis and comparison of mRNA stabilities, overview | Macaca mulatta |
Protein Variants | Comment | Organism |
---|---|---|
additional information | C74A and G223A are naturally occuring, nonsynonymous single nucleotide polymorphisms | Macaca mulatta |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, about, recombinant enzyme, SDS-PAGE | Macaca mulatta |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Macaca mulatta | the enzyme is involved in neuronal serotonin, i.e. 5-hydroxytryptamine, biosynthesis, genetic variance is associated with numerous behavioral traits and psychiatric disorders | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Macaca mulatta | Q2HZ26 | - |
- |
no activity in Rattus norvegicus | - |
PC-12 cells | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Macaca mulatta | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is involved in neuronal serotonin, i.e. 5-hydroxytryptamine, biosynthesis, genetic variance is associated with numerous behavioral traits and psychiatric disorders | Macaca mulatta | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, about, recombinant enzyme, SDS-PAGE | Macaca mulatta |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Macaca mulatta |
tryptophan hydroxylase-2 | - |
Macaca mulatta |